The search for an autoimmune origin of psychotic disorders: Prevalence of autoantibodies against hippocampus antigens, glutamic acid decarboxylase and nuclear antigens

The etiology of psychotic disorders is still unknown, but in a subgroup patients symptoms might be caused by an autoimmune reaction. In this study, we tested patterns reactivity against potentially novel hippocampal antigens. Serum cohort 621 individuals with and 257 controls were first for on neuropil rat brain sections. Brain reactive sera (67 diseased, 27 healthy) further antibody binding to glutamic acid decarboxylase (GAD) isotype 65 67 cell-based assay (CBA). A sub-cohort 199 152 was the prevalence anti-nuclear antibodies (ANA) HEp2-substrate as well double-stranded DNA, ribosomal P (RPP), cardiolipin (CL). Incubation serum resulted unidentified both diseased control groups. Upon screening GAD CBA, one these identified GAD65 individual schizophrenia also healthy individual. Two two had low levels targeting GAD67 CBA. Antibody HEp-2-substrate increased schizoaffective disorder, only 3 did testing hint at possible diagnosis systemic lupus erythematosus. Although intracellular antigens no specific targets could identified. are very rare do not seem disorders.